Anti-CD11c Monoclonal Antibody (Clone:BU15)

CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.

Product Specifications

Product Name Alternative

ITGAX||CD11C

Gene Name

ITGAX

Gene ID

3687

UniProt

P20702

Host

Mouse

Reactivity

Human, Monkey

Immunogen

Dendritic cells of synovial fluid

Target Antigen

CD11c

Clonality

Monoclonal

Clone

BU15

Applications

FACS, IP, IHC-Fr

Purification

Purified by protein-A affinity chromatography

Format

Purified

Storage Conditions

Store at 2-8°C. Do not freeze.

Isotype

Mouse IgG1

Curated Selection

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