Anti-CD42b / GPIb alpha Monoclonal Antibody (Clone:HIP1)

CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.

Product Specifications

Product Name Alternative

GP1BA

Gene Name

GP1BA

Gene ID

2811

UniProt

P07359

Host

Mouse

Reactivity

Human, Non-Human Primates

Immunogen

Peripheral blood mononuclear cells of a patient suffering with CLL.

Target Antigen

CD42b

Clonality

Monoclonal

Clone

HIP1

Applications

FACS, IHC-Fr, Functional Assay

Purification

Purified by protein-A affinity chromatography

Format

Purified

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Flow Cytometry Immunohistochemistry (frozen sections) Functional Application The antibody HIP1 inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF) to platelets and ristocetin-induced platelet agglutination.