Anti-LAT Monoclonal Antibody (Clone:LAT-01)
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Product Specifications
Product Name Alternative
Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, p36-38
Gene Name
LAT
Gene ID
27040
UniProt
O43561
Host
Mouse
Reactivity
Human
Immunogen
Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT.
Target Antigen
LAT
Clonality
Monoclonal
Clone
LAT-01
Applications
WB
Purification
Purified by protein-A affinity chromatography
Format
Purified
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Isotype
Mouse IgG1
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
