Anti-CD253 / TRAIL Monoclonal Antibody (Clone:2E5)

Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2) .

Product Specifications

Product Name Alternative

TNFSF10||APO2L||TRAIL

Gene Name

TNFSF10

Gene ID

8743

UniProt

P50591

Host

Mouse

Reactivity

Human

Immunogen

Recombinant soluble fragment (aa 95-281) of human TRAIL.

Target Antigen

CD253 / TRAIL

Clonality

Monoclonal

Clone

2 E 5

Applications

Functional Assay

Purification

Purified by protein-A affinity chromatography

Format

Purified

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Functional Application The antibody 2E5 has high neutralizing activity for human TRAIL in biological assays. Flow Cytometry Recommended dilution:1-10 μg/mL