Anti-CD59 / Protectin Monoclonal Antibody (Clone:MEM-43)

CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC) . It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.

Product Specifications

Product Name Alternative

CD59||MIC11||MIN1||MIN2||MIN3||MSK21

Gene Name

CD59

Gene ID

966

UniProt

P13987

Host

Mouse

Reactivity

Human

Immunogen

Thymocytes and T lymphocytes

Target Antigen

CD59

Clonality

Monoclonal

Clone

MEM-43

Applications

FACS

Purification

Purified by protein-A affinity chromatography

Format

Purified

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Flow cytometry: Recommended dilution: 0.5-4 μg/ml. Immunohistochemistry (paraffin sections) : Recommended dilution: 10 μg/ml; positive tissue: placenta.