Anti-CD56 / NCAM Monoclonal Antibody (Clone:MEM-188)

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.

Product Specifications

Product Name Alternative

NCAM1||NCAM

Gene Name

NCAM1

Gene ID

4684

UniProt

P13591

Host

Mouse

Reactivity

Human

Immunogen

KG-1 human acute myelogenous leukemia cell line

Target Antigen

CD56

Clonality

Monoclonal

Clone

MEM-188

Applications

FACS

Purification

Purified by protein-A affinity chromatography

Format

Purified

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Flow Cytometry Recommended dilution:3 μg/mL Immunoprecipitation Immunohistochemistry Recommended dilution: 1:50 Pretreatment: Heat retrieval (microwave oven) in citrate buffer, standard ABC visualization. Positive tissue: Positive membrane-specific reaction in adjacent peripheral nerve Staining of paraprostatic autonomic ganglion. Staining technique: Standard ABC technique (DAB+) .