Anti-CD6 Monoclonal Antibody (Clone:MEM-98)

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL) . CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.

Product Specifications

Product Name Alternative

CD6

Gene Name

CD6

Gene ID

923

UniProt

P30203

Host

Mouse

Reactivity

Human

Immunogen

Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) .

Target Antigen

CD6

Clonality

Monoclonal

Clone

MEM-98

Applications

FACS, IP, WB, IHC

Purification

Purified by protein-A affinity chromatography

Format

Purified

Storage Conditions

Store at 2-8°C. Do not freeze.

Applications Notes

Flow Cytometry Recommended dilution: 2 μg/mL Immunoprecipitation Western Blotting Application note: Non-reducing conditions. Immunohistochemistry Recommended dilution: 10 μg/mL Positive tissue: spleen