Anti-CD274 / PD-L1 Monoclonal Antibody (Clone:29E.2A3)
CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its ligand CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor (s) for CD274 is likely.
Product Specifications
Product Name Alternative
CD274||B7H1||PDCD1L1||PDCD1LG1||PDL1
Gene Name
CD274
Gene ID
29126
UniProt
Q9NZQ7
Host
Mouse
Reactivity
Human
Immunogen
Full length human CD274
Target Antigen
CD274 / PD-L1
Clonality
Monoclonal
Clone
29E.2A3
Applications
FACS
Purification
Purified by protein-A affinity chromatography
Format
Purified
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow Cytometry Immunohistochemistry (frozen sections) acetone fixation Functional Application blocking
Isotype
Mouse IgG2b
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