Anti-TNF-Alpha (mouse), mAb (blocking) (V1q) (preservative free)

Purified from concentrated hybridoma tissue culture supernatant.Recognizes mouse TNF-Alpha. Reacts with both natural and recombinant mouse TNF-Alpha. It does not cross-react with human TNF-Alpha and TNF-beta (Lymphotoxin-Alpha) .Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-Alpha) is a cytokine involved in systemic inflammation and metabolism and is a member of a group of cytokines that stimulate the acute phase reaction. It causes tumor necrosis in vivo and shows also cytolytic activity against tumors. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors 1 and 2. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-Alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-Alpha. The monoclonal antibody V1q recognizes endogenous mouse TNF-Alpha.