Polyclonal antibody to TRAF-1

This antibody recognizes TRAF1. TRAF1 is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 416 amino acids. The members of this family link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases. TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. TRAFs also interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.