Polyclonal antibody to cIAP-2/HIAP-1

This antibody recognizes cIAP2; which is a 604 amino acid protein belongs to the family of inhibitor of apoptosis proteins (IAP) . Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains. In addition to BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. The IAPs, including cIAP2, have widespread tissue protein expression, with expression levels and subcellular localization patterns differing depending on the cell lineage.