Anti-West Nile Virus, NS1 (Clone WNV-3223)

Specificity: Anti-West Nile virus (Clone WNV-3223) is specific for WNV non-structural protein 1 (NS1) . There is no cross-reactivity with other Flavivirus. Background: West Nile Virus (WNV) is a mosquito-borne, enveloped, positive-stranded RNA flavivirus1. Flavivirus nonstructural protein NS1 has been proposed as an antibody target to avoid antibody-dependent enhancement2. NS1 is a 46-55 kDa glycoprotein that is expressed as a dimer on the cell surface and as a soluble hexamer in the extracellular space and in circulation during infection. WNV NS1 dimer consists of a ß-roll, wing, and ß-ladder.