Anti-Sin Nombre Virus, Glycoprotein (Hantavirus) (Clone SNV-39) -Purified No Carrier Protein

Specificity: The SNV-39 monoclonal antibody is specific for the glycoprotein complex (Gn/Gc) of the Sin Nombre virus (SNV) . It is also capable of binding and neutralizing many OWH isolates. Antigen Distribution: Hantavirus infects and replicates in pulmonary and cardiac endothelium in both humans and deer mice, the natural host. Background: Hantavirus is an enveloped, negative-sensed, single-stranded RNA virus in the bunyavirus family. ?New World? hantaviruses (NWH) are found in the Americas and may cause hantavirus pulmonary syndrome (HPS) . ?Old World? hantaviruses (OWH) are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome. Each hantavirus serotype has a specific rodent host species and is spread by aerosolized urine, feces, saliva, or rodent bites. Sin Nombre Virus (SNV), a NWH first isolated from rodents in the Southwestern United States, infects with a mortality rate of 50%1. SNV-39 specifically targets the glycoprotein complex (Gn/Gc) of SNV, which are essential for the virus's entry into host cells. The antibody binds to these proteins, thereby inhibiting the virus's ability to attach and fuse with the host cell membranes. This neutralizing activity makes SNV-39 a valuable tool in both therapeutic and diagnostic applications2.