Anti-Japanese Encephalitis Virus, NS1 (Clone JEV-4712)

Specificity: Anti-Japanese Encephalitis Virus (Clone JEV-4712) is specific for JEV non-structural protein 1 (NS1) . There is no cross-reactivity with other Flavivirus. Background: Japanese Encephalitis Virus (JEV) is a mosquito-borne, enveloped positive-stranded RNA virus in the Flavivirus genus endemic to Asia and parts of the western Pacific1. Symptomatic JEV infection is most common in children in areas of endemicity or travelers to those regions. Severe symptoms occur in ~1% of cases, with a case-fatality ratio of 20-30%. Survivors often have neurologic, cognitive, or psychiatric sequelae issues. Five JEV genotypes have been identified, and existing vaccines are derived from historically predominant GIII strains2.