Anti-B.anthracis (Anthrax) Protective Antigen (Obiltoxaximab)

Specificity: This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Obiltoxaximab. Clone ETI-204 specifically binds to the protective antigen of Bacillus anthracis, neutralizing its toxic effects. Antigen Distribution: The protective antigen (PA) of Bacillus anthracis binds to endothelial receptors on human cells, facilitating the entry of edema toxin and lethal toxin into the host cells. Background: Obiltoxaximab (Anti-B. Anthracis Protective Antigen) is a chimeric monoclonal antibody specifically designed to target the PA component of Bacillus anthracis toxin. It is used alongside appropriate antibacterial drugs for the treatment and prevention of inhalational anthrax. By binding to the PA component, Obiltoxaximab prevents the anthrax toxin from entering and damaging cells, thereby enhancing survival rates in animal models of inhalational anthrax. This antibody is administered intravenously and must be given in monitored settings due to the risk of hypersensitivity and anaphylaxis1-3. Obiltoxaximab, also known as ETI-204, is a powerful monoclonal antibody designed to target the protective antigen (PA) of Bacillus anthracis. It is a high-affinity chimeric deimmunized antibody with a molecular weight of approximately 148 kDa, combining human constant region sequences with deimmunized murine variable region sequences. Obiltoxaximab plays a critical role in inhibiting the assembly of anthrax toxin and preventing the intoxication of target cells. This action helps promote survival and limit the spread of bacteria in animal models. As an adjunct therapy, ETI-204 has demonstrated significant efficacy in enhancing survival rates when used in combination with antibiotics. Clinical trials have also shown promising results in terms of its safety, tolerability, and pharmacokinetics1-3.