Biotinylated Anti-Dxd antibody (1A12) ; Rabbit mAb
Dxd is a potent anti-cancer drug, acting as an alkaloid camptothecin analog and a DNA topoisomerase I inhibitor. It forms a stable complex with topoisomerase I and DNA, impeding DNA replication and inducing cancer cell death. Dxd is utilized as a payload in specific antibody-drug conjugates (ADCs), with examples such as trastuzumab deruxtecan targeting HER2 and patritumab deruxtecan targeting HER3.
Product Specifications
Product Name Alternative
N.A.
Gene Name
Dxd
UniProt
N.A.
Host
Rabbit
Target Antigen
Dxd
Clonality
Monoclonal
Clone
1A12
Applications
ELISA
Purification
Purified from cell culture supernatant by affinity chromatography
Components
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage Conditions
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.
Applications Notes
ELISA 1:5000-10000
Isotype
IgG
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