Biotinylated Anti-CXCR3 antibody (DM208) ; Rabbit mAb

This gene encodes a G protein-coupled receptor with selectivity for three chemokines; termed CXCL9:Mig (monokine induced by interferon-g) ; CXCL10:IP10 (interferon-g-inducible 10 kDa protein) and CXCL11:I-TAC (interferon-inducible T cell a-chemoattractant) . Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic; most notably integrin activation; cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine; CXCL4:PF4 (PMID:12782716) . [provided by RefSeq; Jun 2011]