Biotinylated Anti-IL2 antibody (DM187) ; Rabbit mAb

This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4; IL7; IL9; IL15; IL21; erythropoietin; and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes; that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic; which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease; which suggests an essential role of this gene in the immune response to antigenic stimuli.