Biotinylated Anti-OX40 antibody (DM116) ; Rabbit mAb

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1:BCL2-XL; and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4 T cell response; as well as in T cell-dependent B cell proliferation and differentiation.