Biotinylated Anti-IL5RA antibody (DMC393) ; IgG1 Chimeric mAb

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3) ; colony stimulating factor 2 (CSF2:GM-CSF) ; and interleukin 5 (IL5) . The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding; and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin) ; which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.