Anti-SEMA4D antibody (11G2), IgG1 Chimeric mAb

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282) . Regulates GABAergic synapse development (By similarity) . Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity) . Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569) . Promotes the migration of cerebellar granule cells (PubMed:16055703) . Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214) . Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703) .[UniProtKB/Swiss-Prot Function]

Product Specifications

Product Name Alternative

A8; BB18; GR3; CD100; C9orf164; CD100; SEMAJ

Gene Name

SEMA4D

UniProt

Q92854

Host

Rabbit

Reactivity

Human

Target Antigen

SEMA4D

Clonality

Monoclonal

Clone

11G2

Applications

FACS

Purification

Purified from cell culture supernatant by affinity chromatography

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 12% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.