EM12-SO2F

EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide in MOLT4 cells[1][2]

Product Specifications

CAS Number

2803819-61-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/em12-so2f.html

Purity

99.15

Solubility

DMSO : 1 mg/mL (ultrasonic)

Smiles

O=S(C1=CC2=C(CN(C(CC3)C(NC3=O)=O)C2=O)C=C1)(F)=O

Molecular Formula

C13H11FN2O5S

Molecular Weight

326.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023.|[2]Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3 (9) :1105-1110.