Anti-GDF15 antibody (DMC474) ; IgG1 Chimeric mAb

Description :Anti-GDF15 antibody (DMC474) ; IgG1 Chimeric mAb This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types; acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia; inflammation; acute injury and oxidative stress. [provided by RefSeq; Aug 2016]

Product Specifications

Product Name Alternative

GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB

UniProt

Q99988

Host

Rabbit

Reactivity

Human

Target Antigen

GDF15

Clonality

Monoclonal

Clone

DMC474

Applications

FACS

Purification

Purified from cell culture supernatant by affinity chromatography

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.