Anti-FGFR4 antibody (DMC460) ; IgG1 Chimeric mAb

Description :Anti-FGFR4 antibody (DMC460) ; IgG1 Chimeric mAbThe protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways; including cell proliferation; cell differentiation; cell migration; lipid metabolism; bile acid biosynthesis; vitamin D metabolism; glucose uptake; and phosphate homeostasis. This protein consists of an extracellular region; composed of three immunoglobulin-like domains; a single hydrophobic membrane-spanning segment; and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors; setting in motion a cascade of downstream signals; ultimately influencing mitogenesis and differentiation. [provided by RefSeq; Aug 2017]

Product Specifications

Product Name Alternative

CD334; JTK2; TKF

UniProt

P22455

Host

Rabbit

Reactivity

Human

Target Antigen

FGFR4

Clonality

Monoclonal

Clone

DMC460

Applications

FACS

Purification

Purified from cell culture supernatant by affinity chromatography

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.