Anti-Rotavirus (Clone: RV6-26)

Reactivity Species : Rotavirus-Virus Expression Host : HEK-293 Endotoxin Level :≤ 1.0 EU/mg as determined by the LAL method. Specificity : RV6-26 activity is directed against a quaternary epitope on VP6. This human monoclonal antibody RV6-26 binds at the viral RNA release pore in the DLP and is able to neutralize RV by inhibiting transcription. Structural data suggest steric hindrance inhibits the transcriptional pore. Background : Rotaviruses (RV) are double-stranded, non-enveloped, icosahedral RNA viruses in the Reoviridae family that cause severe dehydrating diarrhea in infants and children. RV particles are composed of concentric viral protein (VP) layers. The triple-layered particle has an inner capsid layer (VP2), an intermediate capsid layer (VP6), and an outer capsid layer (VP7, VP4) . The transcriptionally active double-layered particle (DLP) consists of VP2 and VP6. VP6 is the most antigenic RV protein in humans. The antibody VH146 gene segment is the site of primary interaction with VP65.