Anti-Eastern Equine Encephalitis Virus (Clone: EEEV-129)

Reactivity Species : Eastern Equine Encephalitis-Virus Expression Host : HEK-293 Endotoxin Level‰¤ 1.0 EU/mg as determined by the LAL method. Specificity : Clone EEEV-129 activity is directed against the B domain of the E2 glycoprotein. Furthermore, human monoclonal antibody EEEV-129 binds strongly to both SINV/EEEV particles and EEEV E2 glycoprotein. The Fab form of EEEV-129 also neutralizes SINV-EEEV efficiently but with reduced potency, suggesting bivalent or tetravalent interactions as an IgG may contribute to optimal neutralization of SINV/EEEV. Competition-binding studies utilizing biolayer interferometry shows that EEEV-129 competes with domain B-specific murine anti-EEEV mAbs. Background : Eastern Equine Encephalitis virus (EEEV), one of the most virulent viruses endemic to North America, is a rare mosquito-borne encephalitic alphavirus in the Togaviridae family. Infection leads to a 30% to 75% mortality rate, and up to 90% of survivors develop ongoing neurologic problems1, 2. On average, seven human cases are confirmed yearly in the United States. EEEV is of particular concern because of its potential aerosol spread and lack of available treatments. EEEV prevalence in mosquitoes that feed on humans has recently increased.