Anti-Henipavirus (Clone: HENV-117)

Reactivity Species : Henipavirus‹...Virus Expression Host : HEK-293 Endotoxin Level :≤ 1.0 EU/mg as determined by the LAL method Specificity: HENV-117 activity is directed against the receptor-binding domain of receptor binding protein (RBP) . HENV-117, has shown to neutralizes HeV, NiVM, or NiVB with exceptional potency according to the literature and HENV-117 maps to the receptor-binding domain of HeV-RBP and displays a receptor-blocking phenotype. Binding decreases substantially in the presence of ephrin-B2, indicating HENV-117 neutralizes by blocking binding of virus to host cells. nsEM mapping shows that HENV-117 mimics ephrin-B2 binding.

Product Specifications

Host

Human

Immunogen

HENV-117 was isolated from circulating B cells of an individual exposed to equine HeV vaccine.

Clonality

Monoclonal

Clone

HENV-117

Applications

FACS

Purification

>=95% monomer by analytical SEC

Components

>= 5.0 mg/mL. This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.

Storage Conditions

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at >= -70°C. Avoid Repeated Freeze Thaw Cycles.