Recombinant Anti-Monkeypox L1 Antibody (Clone: MPXV-26)

Reactivity Species: Vaccinia, Variola, Cowpox, Monkeypox, Virus Expression Host: HEK-293 Endotoxin Level:≤ 1.0 EU/mg as determined by the LAL method Specificity: MPXV-26 is reactive against L1, an MV surface protein. Complementary screening approaches were used to identify orthopoxvirus-specific mAbs to MPXV, cowpox virus (CPXV), variola virus (VARV), and vaccinia virus (VACV) . MPXV-26 is reactive to VACV antigen, CPXV lysate, VARV antigen and lysate, but not MPXV lysate. MPXV-26 binds to VACV and VARV purified antigens and CPXV virus-infected cell lysate but not VACV and MPXV cell lysates. MPXV-26 neutralizes VACV MV and MV plus complement (MV+C'), CPXV MV and MV+C', and weakly neutralizes MPXV MV and MV+C'. With cocktail of anti-monkeypox mAbs, neutralization and cross-neutralization are more efficient than in individual assays5. These mAb mixes also provide protection against VACV in mice. While not completely protective on its own, MPXV-26 induces delayed morbidity and mortality in mice, and mixes that exclude MPXV-26 are less effective prophylactics.