Phospho-Lamin A/C (Ser22) (Clone: CF12) rabbit mAb
Lamins are nuclear membrane proteins that are involved with cell cycle control, chromatin organization, and DNA replication (1,2) . Upon caspase 6 cleavage, lamin A/C serves as a molecular marker for capspase 6 activity. Lamin A/C is cleaved during cellular apoptosis into a large (41-50 kDa) as well as a small (28 kDa) fragment leading to nuclear dysfunction and cell death (3) Phosphorylation of lamin A/C at Ser32 by MAPK/CDK signals cell cycle progression and mitosis (4,5) .
Product Specifications
Product Name Alternative
Prelamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser22 of human phospho Lamin A/C
Clonality
Monoclonal
Clone
LaminACS22-CF12
Applications
FACS, WB
Format
Purified
Components
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage Conditions
Store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Rabbit IgG1k
Conjugate
Unconjugated
Frequently Asked Questions
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