Phospho-mTOR (Ser2448) (Clone: E11) rabbit mAb
MTOR, mammalian target of rapamycin, is a Serine/Threonine protein kinase (1-2) that functions as an amino acid and ATP sensor to balance cell growth and nutrient availability (3-4) . When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of 4E-BP1 (5) . mTOR plays a key role in homeostasis and cell growth, and phospho mTOR may be abnormally regulated in tumors. mTOR is a potential target for anti-cancer therapy (6) .
Product Specifications
Product Name Alternative
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser2448 of human phospho mTOR
Clonality
Monoclonal
Clone
MTORS2448-E11
Applications
FACS
Format
Purified
Components
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage Conditions
Store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Rabbit IgG1k
Conjugate
Unconjugated
Frequently Asked Questions
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