Phospho-MKK3 (S189) /MKK6 (S207) (Clone: D3) rabbit mAb PE conjugate
MKK3 and MKK6 are closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5) . Phospho MKK3 and phospho MKK6 both phosphorylate and activate p38. p38 phosphorylation dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines (4,5) . Phospho MKK3 and phospho MKK6 activation occurs through phosphorylation at S189 and T222 on MKK3 (2) and S207 and T211 on MKK6 (4,5) .
Product Specifications
Product Name Alternative
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser189 of human phospho MKK3 and Ser207 of human phospho MKK6.
Clonality
Monoclonal
Clone
MKK3S189MKK6S207-D3
Applications
FACS
Format
Conjugated
Components
1X PBS, 0.09% NaN3, 0.2% BSA
Storage Conditions
Store at 2-8°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Rabbit IgG1k
Conjugate
PE
Frequently Asked Questions
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