Phospho-MSK1 (Thr581) (Clone: A5) rabbit mAb APC conjugate

MSK1 (mitogen and stress activated protein kinase 1, phospho MSK1) is activated by Erk in response to growth factors and by and p38 in response to cellular stress (1) . MSK1 is similar to RSK1 in that it has two kinase domains and a connecting regulatory linker region (2) . S364/S381 phosphorylation activates RSK1 (3), which is analogous to residues S360 and S376 of MSK1, which may be important for phospho MSK1 activity.

Product Specifications

Product Name Alternative

Ribosomal protein S6 kinase alpha-5, S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RSKL, RPS6KA5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Thr581 of human phospho MSK1

Clonality

Monoclonal

Clone

MSK1T581-A5

Applications

FACS

Format

Conjugated

Components

1X PBS, 0.09% NaN3, 0.2% BSA

Storage Conditions

Store at 2-8°C. Avoid repeated freeze and thaw cycles.

Applications Notes

For flow cytometric staining, the suggested use of this reagent is 5 μL per million cells or 5 μL per 100 μL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.