Phospho-Ship2 (Tyr1135) (Clone: 1D2) rabbit mAb
Ship2 (SH2-containing inositol phosphatase 2, phospho Ship2) is a homolog of Ship1. Ship2 is highly expressed in the heart, in skeletal muscle, and in the placenta (1) . SHIP2 negatively regulates insulin signaling (2), and Ship2 polymorphisms have been linked to hyperglycemia (3) . Phospho Ship2 has been identified as a potential therapeutic target for the treatment of obesity and type 2 diabetes (4,5) . The Ship2 residue Tyr1135 is phosphorylated in human cancer cells (6-8) .
Product Specifications
Product Name Alternative
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr1135 of human phospho Ship2
Clonality
Monoclonal
Clone
Ship2Y1135-1D2
Applications
FACS
Format
Purified
Components
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage Conditions
Store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Rabbit IgG1k
Conjugate
Unconjugated
Frequently Asked Questions
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