Phospho-Stat6 (Tyr641) (Clone: G12) rabbit mAb
The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4), after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes, Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis; a large immunohistochemistry study of Stat6 expression in over 2,000 tumor samples confirmed strong nuclear staining.
Product Specifications
Product Name Alternative
Signal transducer and activator of transcription 6, IL-4 Stat
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
Clonality
Monoclonal
Clone
Stat6Y641-G12
Applications
FACS, WB
Format
Purified
Components
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage Conditions
Store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Rabbit IgG1k
Conjugate
Unconjugated
Frequently Asked Questions
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