Anti-Tyrosinase (Melanoma Marker) Recombinant Rabbit Monoclonal Antibody (Clone:TYR/2024R)
Selected Variant
12-1262-100
Size: 100 µg
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Product Specifications
Product Name Alternative
ATN, CMM8, LB24-AB, Monophenol monooxygenase, OCA1, OCA1A, Oculocutaneous albinism IA, SHEP3, SK29-AB, Tumor rejection antigen AB, TYR
Gene Name
TYR
Gene ID
7299
UniProt
P14679
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant tyrosinase protein
Clonality
Monoclonal
Clone
TYR/2024R
Applications
IHC
Purification
Protein A/G
Format
Purified
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Isotype
Rabbit IgG
Price
Frequently Asked Questions
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