Recombinant Rabbit Monoclonal Antibody to IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) (Clone : IG507R)

Recognizes a protein of 75kDa, identified as gamma heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), mu (IgM), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This antibody is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Product Specifications

Product Name Alternative

G1m Marker, G2m Marker, G3m Marker, G4m Marker, HDC, Heavy Chain Disease Protein, Human Immunglobulin G, Ig gamma1/2/3/4 Chain C Region, IGHG1, IGHG2, IGHG3, IGHG4, Immunoglobulin Heavy Constant ? 1/2/3/4

Gene Name

IGHG

Gene ID

3500 (IGHG1), 3501 (IGHG2), 3502 (IGHG3), 3503 (IG

UniProt

P01857, P01859, P01860, P01861

Reactivity

Human

Immunogen

Purified human Ig Gamma Chain

Target Antigen

IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker)

Clonality

Monoclonal

Clone

IG507R

Applications

IHC

Purification

Purified Ab with BSA and Azide at 200ug/ml

Format

Purified

Components

200ug/mL of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

Known Applications &Suggested DilutionsImmunohistochemistry (Formalin-fixed) (1-2μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes)