Polyclonal Antibody to SAPK interacting protein 1/Mip1
Stress-activated map kinase (SAPK) -interacting protein 1, also called as Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1), belongs to Stress-activated map kinase interacting protein 1 (SIN1) family. It is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors and also plays a critical role in AKT1 'Ser-473' phosphorylation. Except isoform 4 from its 6 isoforms , all can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. It is ubiquitously expressed in heart and skeletal muscle. Diseases associated with MAPKAP1 include bronchiolitis obliterans organizing pneumonia and nephrogenic systemic fibrosis.
Product Specifications
Product Name Alternative
MAPKAP1||MIP1||SIN1
Gene Name
MAPKAP1
Gene ID
79109
UniProt
Q9BPZ7
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant Mip1 protein (amino acids 250-522) was used as the immunogen for this antibody.
Target Antigen
SAPK interacting proten 1/Mip1
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-3 μg/mL
Isotype
Rabbit IgG
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