Polyclonal Antibody to HOIL-1L/RBCK1
RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1) is a transcription factor belonging to the RING-IBR protein family. It shuttles between the nucleus and cytoplasm, possessing both the nuclear export and localization signals within its amino acid sequence. RBCK1 deficiency causes polyglucosan storage myopathy associated with progressive muscle weakness and cardiomyopathy. RBCK1 negatively regulates the cellular antiviral response. RBCK1 regulates cell cycle progression and proliferation of ERalpha (estrogen receptor alpha) -positive breast cancer cells by supporting transcription of ERalpha and cyclin B1.
Product Specifications
Product Name Alternative
RBCK1||C20orf18||RNF54||UBCE7IP3||XAP3||XAP4
Gene Name
RBCK1
Gene ID
10616
UniProt
Q9BYM8
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant HOIL-1L/RBCK1 protein (amino acids 121-333) was used as the immunogen for this antibody.
Target Antigen
HOIL-1L/RBCK1
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL
Isotype
Rabbit IgG
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