Polyclonal Antibody to CUEDC2
CUE domain-containing protein 2 commonly known as CUEDC2 is a 32 kDa protein having CUE Domain. It is involved in ubiquitin and proteasome-mediated degradation of progesterone receptor and estrogen receptor. It interacts with PRB isoform of progesterone receptor (PR) and modulates estrogen receptor (ER) -alpha protein stability through the ubiquitin-proteasome pathway. High level expression of CUEDC2 found in breast cancer tissue compared to normal adjacent tissue. It is found that CUEDC2 has some role in regulating IKK dephosphorylation by recruiting PP1.
Product Specifications
Product Name Alternative
CUEDC2||C10orf66||HOYS6
Gene Name
CUEDC2
Gene ID
79004
UniProt
Q9H467
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant CUEDC2 protein (amino acids 100-280) was used as the immunogen for this antibody.
Target Antigen
CUEDC2
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2μg/mL
Isotype
Rabbit IgG
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