Polyclonal Antibody to NR2F6
NR2F6 (Nuclear receptor subfamily 2 group F member 6) is a nuclear zinc-finger orphan receptor which acts as a critical PKC (protein kinase C) substrate and essential regulator of CD4 (+) T cell activation responses. It Inhibits NFATC (Nuclear factor of activated T-cells) transcription factor DNA binding and subsequently its transcriptional activity. It acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. It is involved in development of forebrain circadian clock.
Product Specifications
Product Name Alternative
NR2F6||EAR2||ERBAL2
Gene Name
NR2F6
Gene ID
2063
UniProt
P10588
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant NR2F6 protein (amino acids 210-400) was used as the immunogen for this antibody.
Target Antigen
NR2F6
Clonality
Polyclonal
Applications
IHC, WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL, Immunohistochemical analysis: 5 μg/mL
Isotype
Rabbit IgG
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