Polyclonal Antibody to Tis7
Tis7/IFRD1 (interferon-related developmental regulator 1) is expressed by neutrophils as a key modifier gene in cystic fibrosis (CF) lung disease. It functions as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. In skeletal muscle cells, Tis7 is known to function as a coactivator of MyoD by promoting the transcriptional activity of myocyte enhancer factor 2C (MEF2C) . Mutations in Tis7 are associated with sensory/motor neuropathy with ataxia.
Product Specifications
Product Name Alternative
IFRD1
Gene Name
IFRD1
Gene ID
3475
UniProt
O00458
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant Tis7 protein (amino acids 1-300) was used as the immunogen for this antibody.
Target Antigen
Tis7
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4μg/mL
Isotype
Rabbit IgG
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