Polyclonal Antibody to TLR1

Toll/interleukin-1 receptor-like protein (TLR1) is a member of the Toll-like receptor (TLR) family, which has close similarity to Drosophila Toll homologs. Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo. TLR1 is a type I transmembrane receptor that characteristically contains an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLRs generally exist as homodimers, but TLR6 forms heterodimers with TLR2 and binds lipopeptide components of gram-positive and gram-negative bacterial cell walls. TLR1 is found to be involved in ocular toxoplasmosis and leprosy. It is highly expressed in spleen, ovary, peripheral blood leukocytes, thymus, and small intestine.