Polyclonal Antibody to Mouse TLR4
TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types.
Product Specifications
Product Name Alternative
Toll-like receptor 4, CD284
Gene Name
Tlr4
Gene ID
21898
UniProt
Q9QUK6
Host
Rabbit
Reactivity
Mouse
Immunogen
A partial length recombinant m TLR4 protein (amino acids 400-650) was used as the immunogen for this antibody.
Target Antigen
M TLR4
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL
Isotype
Rabbit IgG
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