Polyclonal Antibody to DEPTOR/DEPDC6
DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. DEPTOR expression is required to maintain PI3K and Akt activation and to inhibit apoptosis. DEPTOR is expressed in different microvascular ECs (endothelial cells) . It plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells (ESCs) . It is overexpressed in RPMI-8226 human multiple myeloma cells, and plays an important role in maintaining cell survival.
Product Specifications
Product Name Alternative
DEPTOR||DEPDC6
Gene Name
DEPTOR
Gene ID
64798
UniProt
Q8TB45
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant DEPTOR protein (amino acids 111-301) was used as the immunogen for this antibody.
Target Antigen
DEPTOR/DEPDC6
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL
Isotype
Rabbit IgG
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