Polyclonal Antibody to 14-3-3 Zeta
14-3-3zeta is a central cellular hub protein regulating multiple signaling pathways involved in cancer development, progression and therapeutic resistance. It is linked to endoplasmic reticulum (ER) function in neurons, with reduced levels provoking ER stress and increasing vulnerability to excitotoxic injury. It is up-regulated in malignancy, which suggests its potential as a putative drug target for the treatment of colorectal cancer and tumorgenesis in pancreas, EOC (epithelial ovarian cancer) .
Product Specifications
Product Name Alternative
YWHAZ
Gene Name
YWHAZ
Gene ID
7534
UniProt
P63104
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant 14-3-3 Zeta protein (amino acids 48-245) was used as the immunogen for this antibody.
Target Antigen
14-3-3 Zeta
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4μg/mL
Isotype
Rabbit IgG
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