Polyclonal Antibody to Caspase-12
Caspase 12 belongs to a family of enzymes called caspases that is highly related to members of the ICE subfamily. Other caspases cleave their substrates at C-terminal aspartic acid residue but caspase 12 does not have protease properties rather it processes inflammatory cytokines. It is involved in the activation cascade of caspases responsible for apoptosis execution. Diseases associated with CASP12 include sepsis and prion disease. Caspase 12 is mainly expressed in skeletal muscle and lung.
Product Specifications
Product Name Alternative
CASP12||UNQ9415/PRO34398
Gene Name
CASP12
Gene ID
100506742
UniProt
Q6UXS9
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant Caspase-12 protein (amino acids 100-321) was used as the immunogen for this antibody.
Target Antigen
Caspase-12
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 4-6 μg/mL
Isotype
Rabbit IgG
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