Polyclonal Antibody to Survivin

Survivin is the smallest mammalian member of the IAP (Inhibitor-Of-Apoptosis) gene family. It regulates two essential cellular processes; inhibits apoptosis and promotes cell proliferation. Survivin also plays a main role in cancer progression because it prevents apoptosis by inhibition of caspase 3 and caspase 7, and by regulating the G2 and M phases of the cell cycle. Overexpression of survivin is associated with neoplasia and metastasis. Survivin might be used as a biomarker and a primary chemotherapeutic target for the detection and treatment of gastrointestinal tract cancer, especially esophageal, gastric, and colon cancers.