Polyclonal Antibody to CYP1B1
CYP1B1 (Cytochrome P450 1B1) belongs to the CYP450 superfamily of heme-binding mono-oxygenases which catalyze oxidation of various endogenous and exogenous substrates. The expression of Cyp1b1 plays an important role in the modulation of development and functions of the trabecular meshwork (TM) . Mutations in Cyp1b1 found in patients with primary congenital glaucoma (PCG) .It plays an important role in breast cancer development and progression by bioactivating endogenous estrogens and environmental carcinogens. It is over-expressed at the early stage of NNK-induced lung tumorigenesis.
Product Specifications
Product Name Alternative
CYP1B1
Gene Name
CYP1B1
Gene ID
1545
UniProt
Q16678
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant CYP1B1 protein (amino acids 1-260) was used as the immunogen for this antibody.
Target Antigen
CYP1B1
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL
Isotype
Rabbit IgG
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