SARS CoV2 Spike S1 Antibody (Clone: ABM1G2.1F7)
The spike (S) protein of nCoV/SARS-CoV-2/COVID-19 is one of the structural glycoproteins that remains embedded in viral envelope and acts as the fundamental component of early viral infection of nCoV/SARS-CoV-2/COVID-19 upon binding the host receptor. The nCoV/SARS-CoV-2/COVID-19 has a trimeric spike protein which has two main domains such as S1 domain for receptor binding and S2 domain for membrane fusion and several specific cleavage sites in S1- S2 boundary junction that needs a novel, endocytic protease- primed cleavage to get activated during infection. It mainly binds to the furin protein on the cell membrane which performs trypsin like proteolytic cleavage and then the protein gets activated facilitating its entry into the host. This transmembrane spike protein of nCoV/SARS-CoV-2/COVID-19 shares binding property to the Angiotensin Converting Enzyme 2 (ACE2) likely to that of SARS- CoV. The high affinity of nCoV/SARS-CoV-2/COVID-19 Spike protein for human ACE2 may contribute to the apparent ease with which nCoV/SARS-CoV-2/COVID-19 can spread from human-to-human and make nCoV/SARS-CoV-2/COVID-19 pandemic.
Product Specifications
Product Name Alternative
NCov, Sars-Cov-2
Gene Name
S
Gene ID
43740568
UniProt
P0DTC2
Host
Mouse
Immunogen
The target protein is expressed with sequence (AA 14-683) of SARS-CoV-2/COVID-19 Spike S1 sequence fused with a 10-His tag in C-Terminal.
Clonality
Monoclonal
Clone
ABM1G2.1F7
Applications
WB
Purification
Protein G Purification
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Recommended dilutions: WB: 0.5-1 μg/mL. However, this need to be optimized based on the research applications.
Isotype
Mouse IgG1, Kappa
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