Monoclonal Antibody to Mouse PD-1 (Clone: ABM5F42)
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Product Specifications
Product Name Alternative
Programmed cell death protein 1, Protein PD-1, CD279
Gene Name
Pdcd1
Gene ID
18566
UniProt
Q02242
Host
Rat
Reactivity
Mouse
Immunogen
Partial length recombinant protein (a.a 07-211) of mPD-1 was used as the immunogen for this antibody.
Target Antigen
MPD-1
Clonality
Monoclonal
Clone
ABM5F42
Applications
FACS
Purification
Protein G Chromatography
Format
Purified
Components
100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
FACS: 0.5-1 μg/10^6
Isotype
Rat IgG2b, kappa
Conjugate
Unconjugated
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